Antiplasmodial activities of gold(I) complexes involving functionalized N-heterocyclic carbenes
Identifieur interne : 000124 ( France/Analysis ); précédent : 000123; suivant : 000125Antiplasmodial activities of gold(I) complexes involving functionalized N-heterocyclic carbenes
Auteurs : Catherine Hemmert [France] ; Arba Pramundita Ramadani [France] ; Luca Boselli [France] ; Alvaro Fernandez Alvarez [France] ; Lucie Paloque [France] ; Jean-Michel Augereau [France] ; H. Gornitzka [France] ; F. Benoit-Vical [France]Source :
- Bioorganic and Medicinal Chemistry [ 0968-0896 ] ; 2016.
Abstract
A series of twenty five molecules, including imidazolium salts functionalized by N-, O- or S-containing groups and their corresponding cationic, neutral or anionic gold(I) complexes were evaluated on Plasmodium falciparum in vitro and then on Vero cells to determine their selectivity. Among them, eight new compounds were synthesized and fully characterized by spectroscopic methods. The X-ray structures of three gold(I) complexes are presented. Except one complex (18), all the cationic gold(I) complexes show potent antiplasmodial activity with IC50 in the micro-and submicromolar range, correlated with their lipophilicity. Structure-activity relationships enable to evidence a lead-complex (21) displaying a good activity (IC50 = 210 nM) close to the value obtained with chloroquine (IC50 = 514 nM) and a weak cytotoxicity. (C) 2016 Elsevier Ltd. All rights reserved.
Url:
DOI: 10.1016/j.bmc.2016.05.023
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000021
- to stream Hal, to step Curation: 000021
- to stream Hal, to step Checkpoint: 000084
- to stream Main, to step Merge: 000D48
- to stream Main, to step Curation: 000D47
- to stream Main, to step Exploration: 000D47
- to stream France, to step Extraction: 000124
Links to Exploration step
Hal:hal-01937596Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antiplasmodial activities of gold(I) complexes involving functionalized N-heterocyclic carbenes</title><author><name sortKey="Hemmert, Catherine" sort="Hemmert, Catherine" uniqKey="Hemmert C" first="Catherine" last="Hemmert">Catherine Hemmert</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-461" status="VALID"> <idno type="IdRef">190242221</idno> <idno type="ISNI">0000 0004 0638 384X</idno> <idno type="RNSR">197417418A</idno> <orgName>Laboratoire de chimie de coordination</orgName> <orgName type="acronym">LCC</orgName> <date type="start">1974-01-01</date> <desc> <address> <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.lcc-toulouse.fr</ref> </desc> <listRelation> <relation active="#struct-448187" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-159253" type="direct"></relation> <relation active="#struct-67872" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation name="UPR8241" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-448187" type="direct"><org type="institution" xml:id="struct-448187" status="VALID"> <idno type="IdRef">026388820</idno> <idno type="ISNI">0000000121766169</idno> <orgName>Institut National Polytechnique (Toulouse)</orgName> <orgName type="acronym">Toulouse INP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName> <desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno> <idno type="ISNI">0000000121617331</idno> <orgName>Université Toulouse III - Paul Sabatier</orgName> <orgName type="acronym">UT3</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-159253" type="direct"><org type="regrouplaboratory" xml:id="struct-159253" status="VALID"> <idno type="IdRef">240309472</idno> <idno type="ISNI">0000 0004 4686 8315</idno> <idno type="RNSR">200310667L</idno> <orgName>Institut de Chimie de Toulouse</orgName> <orgName type="acronym">ICT-FR 2599</orgName> <desc> <address> <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://ict.ups-tlse.fr/</ref> </desc> <listRelation> <relation active="#struct-67872" type="direct"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation active="#struct-448187" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-67872" type="indirect"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle name="FR2599" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="UPR8241" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Ramadani, Arba Pramundita" sort="Ramadani, Arba Pramundita" uniqKey="Ramadani A" first="Arba Pramundita" last="Ramadani">Arba Pramundita Ramadani</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-461" status="VALID"> <idno type="IdRef">190242221</idno> <idno type="ISNI">0000 0004 0638 384X</idno> <idno type="RNSR">197417418A</idno> <orgName>Laboratoire de chimie de coordination</orgName> <orgName type="acronym">LCC</orgName> <date type="start">1974-01-01</date> <desc> <address> <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.lcc-toulouse.fr</ref> </desc> <listRelation> <relation active="#struct-448187" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-159253" type="direct"></relation> <relation active="#struct-67872" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation name="UPR8241" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-448187" type="direct"><org type="institution" xml:id="struct-448187" status="VALID"> <idno type="IdRef">026388820</idno> <idno type="ISNI">0000000121766169</idno> <orgName>Institut National Polytechnique (Toulouse)</orgName> <orgName type="acronym">Toulouse INP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName> <desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno> <idno type="ISNI">0000000121617331</idno> <orgName>Université Toulouse III - Paul Sabatier</orgName> <orgName type="acronym">UT3</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-159253" type="direct"><org type="regrouplaboratory" xml:id="struct-159253" status="VALID"> <idno type="IdRef">240309472</idno> <idno type="ISNI">0000 0004 4686 8315</idno> <idno type="RNSR">200310667L</idno> <orgName>Institut de Chimie de Toulouse</orgName> <orgName type="acronym">ICT-FR 2599</orgName> <desc> <address> <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://ict.ups-tlse.fr/</ref> </desc> <listRelation> <relation active="#struct-67872" type="direct"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation active="#struct-448187" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-67872" type="indirect"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle name="FR2599" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="UPR8241" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Boselli, Luca" sort="Boselli, Luca" uniqKey="Boselli L" first="Luca" last="Boselli">Luca Boselli</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-461" status="VALID"> <idno type="IdRef">190242221</idno> <idno type="ISNI">0000 0004 0638 384X</idno> <idno type="RNSR">197417418A</idno> <orgName>Laboratoire de chimie de coordination</orgName> <orgName type="acronym">LCC</orgName> <date type="start">1974-01-01</date> <desc> <address> <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.lcc-toulouse.fr</ref> </desc> <listRelation> <relation active="#struct-448187" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-159253" type="direct"></relation> <relation active="#struct-67872" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation name="UPR8241" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-448187" type="direct"><org type="institution" xml:id="struct-448187" status="VALID"> <idno type="IdRef">026388820</idno> <idno type="ISNI">0000000121766169</idno> <orgName>Institut National Polytechnique (Toulouse)</orgName> <orgName type="acronym">Toulouse INP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName> <desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno> <idno type="ISNI">0000000121617331</idno> <orgName>Université Toulouse III - Paul Sabatier</orgName> <orgName type="acronym">UT3</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-159253" type="direct"><org type="regrouplaboratory" xml:id="struct-159253" status="VALID"> <idno type="IdRef">240309472</idno> <idno type="ISNI">0000 0004 4686 8315</idno> <idno type="RNSR">200310667L</idno> <orgName>Institut de Chimie de Toulouse</orgName> <orgName type="acronym">ICT-FR 2599</orgName> <desc> <address> <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://ict.ups-tlse.fr/</ref> </desc> <listRelation> <relation active="#struct-67872" type="direct"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation active="#struct-448187" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-67872" type="indirect"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle name="FR2599" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="UPR8241" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Fernandez Alvarez, Alvaro" sort="Fernandez Alvarez, Alvaro" uniqKey="Fernandez Alvarez A" first="Alvaro" last="Fernandez Alvarez">Alvaro Fernandez Alvarez</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-461" status="VALID"> <idno type="IdRef">190242221</idno> <idno type="ISNI">0000 0004 0638 384X</idno> <idno type="RNSR">197417418A</idno> <orgName>Laboratoire de chimie de coordination</orgName> <orgName type="acronym">LCC</orgName> <date type="start">1974-01-01</date> <desc> <address> <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.lcc-toulouse.fr</ref> </desc> <listRelation> <relation active="#struct-448187" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-159253" type="direct"></relation> <relation active="#struct-67872" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation name="UPR8241" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-448187" type="direct"><org type="institution" xml:id="struct-448187" status="VALID"> <idno type="IdRef">026388820</idno> <idno type="ISNI">0000000121766169</idno> <orgName>Institut National Polytechnique (Toulouse)</orgName> <orgName type="acronym">Toulouse INP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName> <desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno> <idno type="ISNI">0000000121617331</idno> <orgName>Université Toulouse III - Paul Sabatier</orgName> <orgName type="acronym">UT3</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-159253" type="direct"><org type="regrouplaboratory" xml:id="struct-159253" status="VALID"> <idno type="IdRef">240309472</idno> <idno type="ISNI">0000 0004 4686 8315</idno> <idno type="RNSR">200310667L</idno> <orgName>Institut de Chimie de Toulouse</orgName> <orgName type="acronym">ICT-FR 2599</orgName> <desc> <address> <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://ict.ups-tlse.fr/</ref> </desc> <listRelation> <relation active="#struct-67872" type="direct"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation active="#struct-448187" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-67872" type="indirect"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle name="FR2599" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="UPR8241" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Paloque, Lucie" sort="Paloque, Lucie" uniqKey="Paloque L" first="Lucie" last="Paloque">Lucie Paloque</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno> <idno type="ISNI">0000000121617331</idno> <orgName>Université Toulouse III - Paul Sabatier</orgName> <orgName type="acronym">UT3</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-443875" type="direct"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName> <desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Augereau, Jean Michel" sort="Augereau, Jean Michel" uniqKey="Augereau J" first="Jean-Michel" last="Augereau">Jean-Michel Augereau</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-461" status="VALID"> <idno type="IdRef">190242221</idno> <idno type="ISNI">0000 0004 0638 384X</idno> <idno type="RNSR">197417418A</idno> <orgName>Laboratoire de chimie de coordination</orgName> <orgName type="acronym">LCC</orgName> <date type="start">1974-01-01</date> <desc> <address> <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.lcc-toulouse.fr</ref> </desc> <listRelation> <relation active="#struct-448187" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-159253" type="direct"></relation> <relation active="#struct-67872" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation name="UPR8241" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-448187" type="direct"><org type="institution" xml:id="struct-448187" status="VALID"> <idno type="IdRef">026388820</idno> <idno type="ISNI">0000000121766169</idno> <orgName>Institut National Polytechnique (Toulouse)</orgName> <orgName type="acronym">Toulouse INP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName> <desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno> <idno type="ISNI">0000000121617331</idno> <orgName>Université Toulouse III - Paul Sabatier</orgName> <orgName type="acronym">UT3</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-159253" type="direct"><org type="regrouplaboratory" xml:id="struct-159253" status="VALID"> <idno type="IdRef">240309472</idno> <idno type="ISNI">0000 0004 4686 8315</idno> <idno type="RNSR">200310667L</idno> <orgName>Institut de Chimie de Toulouse</orgName> <orgName type="acronym">ICT-FR 2599</orgName> <desc> <address> <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://ict.ups-tlse.fr/</ref> </desc> <listRelation> <relation active="#struct-67872" type="direct"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation active="#struct-448187" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-67872" type="indirect"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle name="FR2599" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="UPR8241" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Gornitzka, H" sort="Gornitzka, H" uniqKey="Gornitzka H" first="H." last="Gornitzka">H. Gornitzka</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-461" status="VALID"> <idno type="IdRef">190242221</idno> <idno type="ISNI">0000 0004 0638 384X</idno> <idno type="RNSR">197417418A</idno> <orgName>Laboratoire de chimie de coordination</orgName> <orgName type="acronym">LCC</orgName> <date type="start">1974-01-01</date> <desc> <address> <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.lcc-toulouse.fr</ref> </desc> <listRelation> <relation active="#struct-448187" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-159253" type="direct"></relation> <relation active="#struct-67872" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation name="UPR8241" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-448187" type="direct"><org type="institution" xml:id="struct-448187" status="VALID"> <idno type="IdRef">026388820</idno> <idno type="ISNI">0000000121766169</idno> <orgName>Institut National Polytechnique (Toulouse)</orgName> <orgName type="acronym">Toulouse INP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName> <desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno> <idno type="ISNI">0000000121617331</idno> <orgName>Université Toulouse III - Paul Sabatier</orgName> <orgName type="acronym">UT3</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-159253" type="direct"><org type="regrouplaboratory" xml:id="struct-159253" status="VALID"> <idno type="IdRef">240309472</idno> <idno type="ISNI">0000 0004 4686 8315</idno> <idno type="RNSR">200310667L</idno> <orgName>Institut de Chimie de Toulouse</orgName> <orgName type="acronym">ICT-FR 2599</orgName> <desc> <address> <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://ict.ups-tlse.fr/</ref> </desc> <listRelation> <relation active="#struct-67872" type="direct"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation active="#struct-448187" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-67872" type="indirect"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle name="FR2599" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="UPR8241" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Benoit Vical, F" sort="Benoit Vical, F" uniqKey="Benoit Vical F" first="F." last="Benoit-Vical">F. Benoit-Vical</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-461" status="VALID"> <idno type="IdRef">190242221</idno> <idno type="ISNI">0000 0004 0638 384X</idno> <idno type="RNSR">197417418A</idno> <orgName>Laboratoire de chimie de coordination</orgName> <orgName type="acronym">LCC</orgName> <date type="start">1974-01-01</date> <desc> <address> <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.lcc-toulouse.fr</ref> </desc> <listRelation> <relation active="#struct-448187" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-159253" type="direct"></relation> <relation active="#struct-67872" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation name="UPR8241" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-448187" type="direct"><org type="institution" xml:id="struct-448187" status="VALID"> <idno type="IdRef">026388820</idno> <idno type="ISNI">0000000121766169</idno> <orgName>Institut National Polytechnique (Toulouse)</orgName> <orgName type="acronym">Toulouse INP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName> <desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno> <idno type="ISNI">0000000121617331</idno> <orgName>Université Toulouse III - Paul Sabatier</orgName> <orgName type="acronym">UT3</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-159253" type="direct"><org type="regrouplaboratory" xml:id="struct-159253" status="VALID"> <idno type="IdRef">240309472</idno> <idno type="ISNI">0000 0004 4686 8315</idno> <idno type="RNSR">200310667L</idno> <orgName>Institut de Chimie de Toulouse</orgName> <orgName type="acronym">ICT-FR 2599</orgName> <desc> <address> <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://ict.ups-tlse.fr/</ref> </desc> <listRelation> <relation active="#struct-67872" type="direct"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation active="#struct-448187" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-67872" type="indirect"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle name="FR2599" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="UPR8241" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-01937596</idno><idno type="halId">hal-01937596</idno><idno type="halUri">https://hal.archives-ouvertes.fr/hal-01937596</idno><idno type="url">https://hal.archives-ouvertes.fr/hal-01937596</idno><idno type="doi">10.1016/j.bmc.2016.05.023</idno><date when="2016">2016</date><idno type="wicri:Area/Hal/Corpus">000021</idno><idno type="wicri:Area/Hal/Curation">000021</idno><idno type="wicri:Area/Hal/Checkpoint">000084</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000084</idno><idno type="wicri:doubleKey">0968-0896:2016:Hemmert C:antiplasmodial:activities:of</idno><idno type="wicri:Area/Main/Merge">000D48</idno><idno type="wicri:Area/Main/Curation">000D47</idno><idno type="wicri:Area/Main/Exploration">000D47</idno><idno type="wicri:Area/France/Extraction">000124</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antiplasmodial activities of gold(I) complexes involving functionalized N-heterocyclic carbenes</title><author><name sortKey="Hemmert, Catherine" sort="Hemmert, Catherine" uniqKey="Hemmert C" first="Catherine" last="Hemmert">Catherine Hemmert</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-461" status="VALID"> <idno type="IdRef">190242221</idno> <idno type="ISNI">0000 0004 0638 384X</idno> <idno type="RNSR">197417418A</idno> <orgName>Laboratoire de chimie de coordination</orgName> <orgName type="acronym">LCC</orgName> <date type="start">1974-01-01</date> <desc> <address> <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.lcc-toulouse.fr</ref> </desc> <listRelation> <relation active="#struct-448187" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-159253" type="direct"></relation> <relation active="#struct-67872" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation name="UPR8241" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-448187" type="direct"><org type="institution" xml:id="struct-448187" status="VALID"> <idno type="IdRef">026388820</idno> <idno type="ISNI">0000000121766169</idno> <orgName>Institut National Polytechnique (Toulouse)</orgName> <orgName type="acronym">Toulouse INP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName> <desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno> <idno type="ISNI">0000000121617331</idno> <orgName>Université Toulouse III - Paul Sabatier</orgName> <orgName type="acronym">UT3</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-159253" type="direct"><org type="regrouplaboratory" xml:id="struct-159253" status="VALID"> <idno type="IdRef">240309472</idno> <idno type="ISNI">0000 0004 4686 8315</idno> <idno type="RNSR">200310667L</idno> <orgName>Institut de Chimie de Toulouse</orgName> <orgName type="acronym">ICT-FR 2599</orgName> <desc> <address> <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://ict.ups-tlse.fr/</ref> </desc> <listRelation> <relation active="#struct-67872" type="direct"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation active="#struct-448187" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-67872" type="indirect"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle name="FR2599" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="UPR8241" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Ramadani, Arba Pramundita" sort="Ramadani, Arba Pramundita" uniqKey="Ramadani A" first="Arba Pramundita" last="Ramadani">Arba Pramundita Ramadani</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-461" status="VALID"> <idno type="IdRef">190242221</idno> <idno type="ISNI">0000 0004 0638 384X</idno> <idno type="RNSR">197417418A</idno> <orgName>Laboratoire de chimie de coordination</orgName> <orgName type="acronym">LCC</orgName> <date type="start">1974-01-01</date> <desc> <address> <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.lcc-toulouse.fr</ref> </desc> <listRelation> <relation active="#struct-448187" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-159253" type="direct"></relation> <relation active="#struct-67872" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation name="UPR8241" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-448187" type="direct"><org type="institution" xml:id="struct-448187" status="VALID"> <idno type="IdRef">026388820</idno> <idno type="ISNI">0000000121766169</idno> <orgName>Institut National Polytechnique (Toulouse)</orgName> <orgName type="acronym">Toulouse INP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName> <desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno> <idno type="ISNI">0000000121617331</idno> <orgName>Université Toulouse III - Paul Sabatier</orgName> <orgName type="acronym">UT3</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-159253" type="direct"><org type="regrouplaboratory" xml:id="struct-159253" status="VALID"> <idno type="IdRef">240309472</idno> <idno type="ISNI">0000 0004 4686 8315</idno> <idno type="RNSR">200310667L</idno> <orgName>Institut de Chimie de Toulouse</orgName> <orgName type="acronym">ICT-FR 2599</orgName> <desc> <address> <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://ict.ups-tlse.fr/</ref> </desc> <listRelation> <relation active="#struct-67872" type="direct"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation active="#struct-448187" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-67872" type="indirect"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle name="FR2599" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="UPR8241" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Boselli, Luca" sort="Boselli, Luca" uniqKey="Boselli L" first="Luca" last="Boselli">Luca Boselli</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-461" status="VALID"> <idno type="IdRef">190242221</idno> <idno type="ISNI">0000 0004 0638 384X</idno> <idno type="RNSR">197417418A</idno> <orgName>Laboratoire de chimie de coordination</orgName> <orgName type="acronym">LCC</orgName> <date type="start">1974-01-01</date> <desc> <address> <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.lcc-toulouse.fr</ref> </desc> <listRelation> <relation active="#struct-448187" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-159253" type="direct"></relation> <relation active="#struct-67872" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation name="UPR8241" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-448187" type="direct"><org type="institution" xml:id="struct-448187" status="VALID"> <idno type="IdRef">026388820</idno> <idno type="ISNI">0000000121766169</idno> <orgName>Institut National Polytechnique (Toulouse)</orgName> <orgName type="acronym">Toulouse INP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName> <desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno> <idno type="ISNI">0000000121617331</idno> <orgName>Université Toulouse III - Paul Sabatier</orgName> <orgName type="acronym">UT3</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-159253" type="direct"><org type="regrouplaboratory" xml:id="struct-159253" status="VALID"> <idno type="IdRef">240309472</idno> <idno type="ISNI">0000 0004 4686 8315</idno> <idno type="RNSR">200310667L</idno> <orgName>Institut de Chimie de Toulouse</orgName> <orgName type="acronym">ICT-FR 2599</orgName> <desc> <address> <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://ict.ups-tlse.fr/</ref> </desc> <listRelation> <relation active="#struct-67872" type="direct"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation active="#struct-448187" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-67872" type="indirect"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle name="FR2599" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="UPR8241" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Fernandez Alvarez, Alvaro" sort="Fernandez Alvarez, Alvaro" uniqKey="Fernandez Alvarez A" first="Alvaro" last="Fernandez Alvarez">Alvaro Fernandez Alvarez</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-461" status="VALID"> <idno type="IdRef">190242221</idno> <idno type="ISNI">0000 0004 0638 384X</idno> <idno type="RNSR">197417418A</idno> <orgName>Laboratoire de chimie de coordination</orgName> <orgName type="acronym">LCC</orgName> <date type="start">1974-01-01</date> <desc> <address> <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.lcc-toulouse.fr</ref> </desc> <listRelation> <relation active="#struct-448187" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-159253" type="direct"></relation> <relation active="#struct-67872" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation name="UPR8241" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-448187" type="direct"><org type="institution" xml:id="struct-448187" status="VALID"> <idno type="IdRef">026388820</idno> <idno type="ISNI">0000000121766169</idno> <orgName>Institut National Polytechnique (Toulouse)</orgName> <orgName type="acronym">Toulouse INP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName> <desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno> <idno type="ISNI">0000000121617331</idno> <orgName>Université Toulouse III - Paul Sabatier</orgName> <orgName type="acronym">UT3</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-159253" type="direct"><org type="regrouplaboratory" xml:id="struct-159253" status="VALID"> <idno type="IdRef">240309472</idno> <idno type="ISNI">0000 0004 4686 8315</idno> <idno type="RNSR">200310667L</idno> <orgName>Institut de Chimie de Toulouse</orgName> <orgName type="acronym">ICT-FR 2599</orgName> <desc> <address> <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://ict.ups-tlse.fr/</ref> </desc> <listRelation> <relation active="#struct-67872" type="direct"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation active="#struct-448187" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-67872" type="indirect"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle name="FR2599" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="UPR8241" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Paloque, Lucie" sort="Paloque, Lucie" uniqKey="Paloque L" first="Lucie" last="Paloque">Lucie Paloque</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno> <idno type="ISNI">0000000121617331</idno> <orgName>Université Toulouse III - Paul Sabatier</orgName> <orgName type="acronym">UT3</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-443875" type="direct"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName> <desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Augereau, Jean Michel" sort="Augereau, Jean Michel" uniqKey="Augereau J" first="Jean-Michel" last="Augereau">Jean-Michel Augereau</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-461" status="VALID"> <idno type="IdRef">190242221</idno> <idno type="ISNI">0000 0004 0638 384X</idno> <idno type="RNSR">197417418A</idno> <orgName>Laboratoire de chimie de coordination</orgName> <orgName type="acronym">LCC</orgName> <date type="start">1974-01-01</date> <desc> <address> <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.lcc-toulouse.fr</ref> </desc> <listRelation> <relation active="#struct-448187" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-159253" type="direct"></relation> <relation active="#struct-67872" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation name="UPR8241" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-448187" type="direct"><org type="institution" xml:id="struct-448187" status="VALID"> <idno type="IdRef">026388820</idno> <idno type="ISNI">0000000121766169</idno> <orgName>Institut National Polytechnique (Toulouse)</orgName> <orgName type="acronym">Toulouse INP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName> <desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno> <idno type="ISNI">0000000121617331</idno> <orgName>Université Toulouse III - Paul Sabatier</orgName> <orgName type="acronym">UT3</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-159253" type="direct"><org type="regrouplaboratory" xml:id="struct-159253" status="VALID"> <idno type="IdRef">240309472</idno> <idno type="ISNI">0000 0004 4686 8315</idno> <idno type="RNSR">200310667L</idno> <orgName>Institut de Chimie de Toulouse</orgName> <orgName type="acronym">ICT-FR 2599</orgName> <desc> <address> <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://ict.ups-tlse.fr/</ref> </desc> <listRelation> <relation active="#struct-67872" type="direct"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation active="#struct-448187" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-67872" type="indirect"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle name="FR2599" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="UPR8241" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Gornitzka, H" sort="Gornitzka, H" uniqKey="Gornitzka H" first="H." last="Gornitzka">H. Gornitzka</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-461" status="VALID"> <idno type="IdRef">190242221</idno> <idno type="ISNI">0000 0004 0638 384X</idno> <idno type="RNSR">197417418A</idno> <orgName>Laboratoire de chimie de coordination</orgName> <orgName type="acronym">LCC</orgName> <date type="start">1974-01-01</date> <desc> <address> <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.lcc-toulouse.fr</ref> </desc> <listRelation> <relation active="#struct-448187" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-159253" type="direct"></relation> <relation active="#struct-67872" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation name="UPR8241" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-448187" type="direct"><org type="institution" xml:id="struct-448187" status="VALID"> <idno type="IdRef">026388820</idno> <idno type="ISNI">0000000121766169</idno> <orgName>Institut National Polytechnique (Toulouse)</orgName> <orgName type="acronym">Toulouse INP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName> <desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno> <idno type="ISNI">0000000121617331</idno> <orgName>Université Toulouse III - Paul Sabatier</orgName> <orgName type="acronym">UT3</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-159253" type="direct"><org type="regrouplaboratory" xml:id="struct-159253" status="VALID"> <idno type="IdRef">240309472</idno> <idno type="ISNI">0000 0004 4686 8315</idno> <idno type="RNSR">200310667L</idno> <orgName>Institut de Chimie de Toulouse</orgName> <orgName type="acronym">ICT-FR 2599</orgName> <desc> <address> <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://ict.ups-tlse.fr/</ref> </desc> <listRelation> <relation active="#struct-67872" type="direct"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation active="#struct-448187" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-67872" type="indirect"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle name="FR2599" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="UPR8241" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Benoit Vical, F" sort="Benoit Vical, F" uniqKey="Benoit Vical F" first="F." last="Benoit-Vical">F. Benoit-Vical</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-461" status="VALID"> <idno type="IdRef">190242221</idno> <idno type="ISNI">0000 0004 0638 384X</idno> <idno type="RNSR">197417418A</idno> <orgName>Laboratoire de chimie de coordination</orgName> <orgName type="acronym">LCC</orgName> <date type="start">1974-01-01</date> <desc> <address> <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.lcc-toulouse.fr</ref> </desc> <listRelation> <relation active="#struct-448187" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-159253" type="direct"></relation> <relation active="#struct-67872" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation name="UPR8241" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-448187" type="direct"><org type="institution" xml:id="struct-448187" status="VALID"> <idno type="IdRef">026388820</idno> <idno type="ISNI">0000000121766169</idno> <orgName>Institut National Polytechnique (Toulouse)</orgName> <orgName type="acronym">Toulouse INP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName> <desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno> <idno type="ISNI">0000000121617331</idno> <orgName>Université Toulouse III - Paul Sabatier</orgName> <orgName type="acronym">UT3</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc> <listRelation> <relation active="#struct-443875" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-159253" type="direct"><org type="regrouplaboratory" xml:id="struct-159253" status="VALID"> <idno type="IdRef">240309472</idno> <idno type="ISNI">0000 0004 4686 8315</idno> <idno type="RNSR">200310667L</idno> <orgName>Institut de Chimie de Toulouse</orgName> <orgName type="acronym">ICT-FR 2599</orgName> <desc> <address> <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://ict.ups-tlse.fr/</ref> </desc> <listRelation> <relation active="#struct-67872" type="direct"></relation> <relation active="#struct-217752" type="direct"></relation> <relation active="#struct-443875" type="indirect"></relation> <relation name="FR2599" active="#struct-441569" type="direct"></relation> <relation active="#struct-448187" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-67872" type="indirect"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName> <orgName type="acronym">IRD</orgName> <desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ird.fr/</ref> </desc> </org></tutelle><tutelle name="FR2599" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="UPR8241" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></analytic><idno type="DOI">10.1016/j.bmc.2016.05.023</idno><series><title level="j">Bioorganic and Medicinal Chemistry</title><idno type="ISSN">0968-0896</idno><imprint><date type="datePub">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>A series of twenty five molecules, including imidazolium salts functionalized by N-, O- or S-containing groups and their corresponding cationic, neutral or anionic gold(I) complexes were evaluated on Plasmodium falciparum in vitro and then on Vero cells to determine their selectivity. Among them, eight new compounds were synthesized and fully characterized by spectroscopic methods. The X-ray structures of three gold(I) complexes are presented. Except one complex (18), all the cationic gold(I) complexes show potent antiplasmodial activity with IC50 in the micro-and submicromolar range, correlated with their lipophilicity. Structure-activity relationships enable to evidence a lead-complex (21) displaying a good activity (IC50 = 210 nM) close to the value obtained with chloroquine (IC50 = 514 nM) and a weak cytotoxicity. (C) 2016 Elsevier Ltd. All rights reserved.</p> </div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Hemmert, Catherine" sort="Hemmert, Catherine" uniqKey="Hemmert C" first="Catherine" last="Hemmert">Catherine Hemmert</name></noRegion><name sortKey="Augereau, Jean Michel" sort="Augereau, Jean Michel" uniqKey="Augereau J" first="Jean-Michel" last="Augereau">Jean-Michel Augereau</name><name sortKey="Benoit Vical, F" sort="Benoit Vical, F" uniqKey="Benoit Vical F" first="F." last="Benoit-Vical">F. Benoit-Vical</name><name sortKey="Boselli, Luca" sort="Boselli, Luca" uniqKey="Boselli L" first="Luca" last="Boselli">Luca Boselli</name><name sortKey="Fernandez Alvarez, Alvaro" sort="Fernandez Alvarez, Alvaro" uniqKey="Fernandez Alvarez A" first="Alvaro" last="Fernandez Alvarez">Alvaro Fernandez Alvarez</name><name sortKey="Gornitzka, H" sort="Gornitzka, H" uniqKey="Gornitzka H" first="H." last="Gornitzka">H. Gornitzka</name><name sortKey="Paloque, Lucie" sort="Paloque, Lucie" uniqKey="Paloque L" first="Lucie" last="Paloque">Lucie Paloque</name><name sortKey="Ramadani, Arba Pramundita" sort="Ramadani, Arba Pramundita" uniqKey="Ramadani A" first="Arba Pramundita" last="Ramadani">Arba Pramundita Ramadani</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000124 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000124 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= France
|étape= Analysis
|type= RBID
|clé= Hal:hal-01937596
|texte= Antiplasmodial activities of gold(I) complexes involving functionalized N-heterocyclic carbenes
}}
| This area was generated with Dilib version V0.6.33. |  |